188 Results for "

Aralia chinensis L.

" in MedChemExpress (MCE) Product Catalog:
Products (188)

188 Results for "Aralia chinensis L." in MCE Product Catalog:

24
Wedelolactone
Wedelolactone
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24 Publications Verification
Cat. No.: HY-N0551
CAS No.: 524-12-9
Category:  

Alysicarpus ovalifolius (Schumacher) J. Leonard Phenols Polyphenols Plants Compositae Disease Research Fields Inflammation/Immunology

Target:  

Caspase Lipoxygenase Apoptosis

Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC50 of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer .
11
Schisandrin B
Schisandrin B
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11 Cited Publications
Cat. No.: HY-N0089
CAS No.: 61281-37-6
Synonyms: γ-Schisandrin; Wuweizisu B
Category:  

Neurological Disease Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer

Target:  

Autophagy Reactive Oxygen Species (ROS)

Schisandrin B (γ-Schisandrin) is a biphenylcyclooctadiene derivative isolated from Schisandra chinensis and has been shown to have antioxidant effects on the liver and heart of rodents.
5
Schisandrin C
Schisandrin C
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5 Cited Publications
Cat. No.: HY-N0690
CAS No.: 61301-33-5
Synonyms: Schizandrin-C; Wuweizisu-C
Category:  

Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer

Target:  

Apoptosis

Schisandrin C (Schizandrin-C) is a phytochemical lignan isolated from Schizandra chinensis . Schisandrin C has diverse biological activities, including anticancer, anti-inflammatory and antioxidant effects. Schisandrin C can be used for cancer, alzheimer’s disease, and liver diseases research . Schisandrin C induces cell apoptosis .
5
Coptisine Sulfate
Coptisine Sulfate
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5 Cited Publications
Cat. No.: HY-N0430A
CAS No.: 1198398-71-8
Category:  

Alkaloids Chelidonium majus Metabolic Disease Quinoline Alkaloids Plants Disease Research Fields Papaveraceae

Target:  

Indoleamine 2,3-Dioxygenase (IDO) NF-κB p38 MAPK PI3K Akt Apoptosis Reactive Oxygen Species (ROS) Mitochondrial Metabolism DNA/RNA Synthesis ROCK LDLR

Coptisine Sulfate is an orally active and brain-penetrant alkaloid found in Coptis chinensis. Coptisine Sulfate is a reversible, uncompetitive IDO inhibitor with a Ki of 5.8 μM and an IC50 of 6.3 μM. Coptisine Sulfate suppresses neuroinflammation, reduces Aβ plaque burden and shows neuroprotective activity. Coptisine Sulfate shows anti-inflammation activity by blocking NF-κB, MAPK, and PI3K/Akt activation. Coptisine Sulfate inhibits cancer cells proliferation, induces DNA damage, G2/M phase cell cycle arrest, apoptosis, ROS production and mitochondrial dysfunction. Coptisine Sulfate inhibits Rho/ROCK pathway activation, reduces arrhythmia, limits cardiac injury marker release, reduces infarct size, and preserves cardiac function in rat myocardial ischemia/reperfusion models. Coptisine Sulfate downregulates HMGCR and upregulates LDLR and CYP7A1 to modulate cholesterol metabolism, reduces abnormal serum lipid levels, and promotes fecal bile acid excretion. Coptisine Sulfate be used for the research of cancer, hypercholesterolemia, Alzheimer’s disease, inflammatory disorders and cardiovascular disease .
4
Irisflorentin
Irisflorentin
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4 Cited Publications
Cat. No.: HY-N0268
CAS No.: 41743-73-1
Category:  

Iridaceae Flavonoids Plants Belamcanda chinensis (Linn.) Redouté Disease Research Fields Inflammation/Immunology Isoflavones

Target:  

NO Synthase

Irisflorentin, a naturally occurring isoflavone, is an abundant active constituent in Belamcanda chinensis. Irisflorentin markedly reduces the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. Anti-inflammatory activity .
4
Epiberberine chloride
Epiberberine chloride
0 Images
4 Cited Publications
Cat. No.: HY-N0226A
CAS No.: 889665-86-5
Category:  

Alkaloids Neurological Disease Ranunculaceae Coptis chinensis Franch. Metabolic Disease Plants Disease Research Fields Isoquinoline Alkaloids

Target:  

Cholinesterase (ChE) Beta-secretase Reactive Oxygen Species (ROS)

Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO - scavenging effect (IC50, 16.83 μM), and may protect against Alzheimer disease . Epiberberine chloride inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways . Epiberberine has the potential effect in the research of diabetic disease .
3
Schisandrin
Schisandrin
0 Images
3 Cited Publications
Cat. No.: HY-N0691
CAS No.: 7432-28-2
Synonyms: Schizandrin; Schizandrol; Schizandrol-A
Category:  

Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer

Target:  

Autophagy

Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats .
3
Leucocyanidin
Leucocyanidin
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3 Cited Publications
Cat. No.: HY-119580
CAS No.: 480-17-1
Purity:  98.03%
Category:  

Flavonoids Microorganisms Litchi Chinensis Sonn. Flavanols Sapindaceae Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Others

Leucocyanidin is an active anti-ulcerogenic ingredient was extracted from Litchi Chinensis. Leucocyanidin demonstrates a significant protective effect against Aspirin-induced erosions in rat models .
3
Jatrorrhizine chloride
Jatrorrhizine chloride
0 Images
3 Cited Publications
Cat. No.: HY-N0740
CAS No.: 6681-15-8
Category:  

Alkaloids Monophenols Ranunculaceae Coptis chinensis Franch. Phenols Plants Isoquinoline Alkaloids

Target:  

Cholinesterase (ChE) 5-HT Receptor Bacterial

Jatrorrhizine chloride is an alkaloid isolated from?Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine chloride is a potent and orally active inhibitor of?AChE?(IC50=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine chloride reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .
3
Jatrorrhizine hydroxide
Jatrorrhizine hydroxide
0 Images
3 Cited Publications
Cat. No.: HY-N0749A
CAS No.: 483-43-2
Category:  

Alkaloids Monophenols Ranunculaceae Coptis chinensis Franch. Phenols Plants Isoquinoline Alkaloids

Target:  

Cholinesterase (ChE) 5-HT Receptor Bacterial

Jatrorrhizine hydroxide is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine hydroxide is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine hydroxide reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .
3
Gomisin J
Gomisin J
0 Images
3 Cited Publications
Cat. No.: HY-N0385
CAS No.: 66280-25-9
Category:  

Cardiovascular Disease Monophenols Lignans Phenols Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill.

Target:  

NO Synthase AMPK CaMK NF-κB Keap1-Nrf2

Gomisin J is a Schisandra chinensis-derived lignan that can inhibit multiple targets such as eNOS, AMPK (LKB1, CaMKIIβ), fetuin-A, NF-κB, Nrf2/HO-1, and can pass through the blood-brain barrier. Gomisin J increases NO bioavailability by activating eNOS, regulates lipid metabolism by activating the AMPK pathway, inhibits fetuin-A and NF-κB to exert anti-inflammatory effects, and activates Nrf2/HO-1 to enhance antioxidant capacity. Gomisin J has the activities of anti-hypertension, regulating liver lipid metabolism, and reducing cerebral ischemia-reperfusion injury, and can be used for research on hypertension, non-alcoholic fatty liver disease, cerebral ischemia-reperfusion injury, etc .
2
Atractylodin
Atractylodin
0 Images
2 Cited Publications
Cat. No.: HY-N0238
CAS No.: 55290-63-6
Synonyms: Atractydin
Category:  

Infection Natural Products Plants Compositae Disease Research Fields Erythrina sigmoidea Hua

Target:  

Insecticide

Atractylodin (Atractydin) is an orally active active ingredient obtained from the rhizome of Atractylodes lancea and A. chinensis. Atractylodin is a natural insecticide. Atractylodin has anti-inflammatory activity .
2
Araloside A
Araloside A
0 Images
2 Cited Publications
Cat. No.: HY-N2115
CAS No.: 7518-22-1
Synonyms: Chikusetsusaponin IV
Category:  

Cardiovascular Disease Triterpenes other families Terpenoids Plants Disease Research Fields Araliaceae

Target:  

Renin Apoptosis Bcl-2 Family Interleukin Related

Araloside A (Chikusetsusaponin IV), triterpenoid saponins, is an orally active component of Aralia elata. Araloside A shows low-renin-inhibitory activity with an IC50 of 77.4 μM. Araloside A can inhibit cell proliferation and induce apoptosis. Araloside A suppresses inflammatory cytokines IL-1β and IL-6 production. Araloside A can be used for the researches of cancer, inflammation and cardiovascular disease, such as renal cell carcinoma and rheumatoid arthritis .
2
Schisandrol B
Schisandrol B
0 Images
2 Cited Publications
Cat. No.: HY-N0692
CAS No.: 58546-54-6
Synonyms: Gomisin-A; TJN-101; Wuweizi alcohol-B
Category:  

Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer

Target:  

Reactive Oxygen Species (ROS) Cytochrome P450 Autophagy

Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities .
2
Bifendate
Bifendate
0 Images
2 Cited Publications
Cat. No.: HY-W018791
CAS No.: 73536-69-3
Synonyms: DDB
Target:  

HBV Autophagy Cytochrome P450 Atg8/LC3 p62 P-glycoprotein

Research Areas:  

Infection Cardiovascular Disease Cancer

Bifendate (DDB), extracted from Schisandrae chinensis, is an orally active anti-HBV agent against chronic hepatitis B. Bifendate inhibits ATG5-dependent autophagy and attenuates oleic acid-induced lipid accumulation with anti-oxidant properties in vitro. Bifendate can decrease alanine transaminase (ALT) level in mice. Bifendate attenuates hepatic steatosis in cholesterol/bile salt- and high-fat diet-induced hypercholesterolemia in mice. Bifendate potently increases the activity of cytochrome proteins (CYPs) and reverse P-gp-mediated multi-drug resistance (MDR) .
1
Pulsatilla saponin D
Pulsatilla saponin D
0 Images
1 Cited Publications
Cat. No.: HY-N0834
CAS No.: 68027-15-6
Synonyms: SB365; Hederacolchiside A
Category:  

Triterpenes Terpenoids Ranunculaceae Plants Disease Research Fields Pulsatilla chinensis (Bunge) Regel Cancer

Target:  

Apoptosis

Pulsatilla saponin D (SB365), isolated from the root of Pulsatilla chinensis, is an anti-tumor agent .
1
Escin IA
Escin IA
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1 Cited Publications
Cat. No.: HY-N0554
CAS No.: 123748-68-5
Category:  

Infection Triterpenes other families Hippocastanaceae Terpenoids Aesculus hippocastanum Plants Disease Research Fields Cancer

Target:  

HIV Protease Monoamine Oxidase

Escin IA is an oral LOXL2 inhibitor and EMT inhibitor, with selectivity for LOXL2-expressing cells. Escin IA suppresses invasion, migration, and metastasis of breast cancer cells, and acts as the primary anti-TNBC metastasis constituent of Aesculus chinensis Bunge fruit saponin fraction. Escin IA can be used for the research of triple-negative breast cancer, acute inflammation, and ethanol-induced gastric mucosal lesions .
1
Dichotomitin
Dichotomitin
0 Images
1 Cited Publications
Cat. No.: HY-N2120
CAS No.: 88509-91-5
Category:  

Iridaceae Flavonoids Other Diseases Phenols Polyphenols Plants Belamcanda chinensis (Linn.) Redouté Disease Research Fields Isoflavones

Target:  

Others

Dichotomitin is an isoflavonoid isolated from the rhizomes of Belamcanda chinensis (L.) DC .
1
Fraxinol
Fraxinol
0 Images
1 Cited Publications
Cat. No.: HY-N2372
CAS No.: 486-28-2
Category:  

other families Monophenols Coumarins Phenols Phenylpropanoids Plants Disease Research Fields Cancer

Target:  

Cytochrome P450

Fraxinol is isolated from Lobelia chinensis .
1
Sauchinone
Sauchinone
0 Images
1 Cited Publications
Cat. No.: HY-N0613
CAS No.: 177931-17-8
Category:  

Saururaceae Saururus chinensis (Lour.) Baill. Terpenoids Diterpenoids Plants Disease Research Fields Inflammation/Immunology

Target:  

NF-κB

Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity .
Assay Types